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Cas11 enables genome engineering in human cells with ...

Tan et al. discover a miniature CRISPR-Cas3 system that can efficiently create targeted large deletions in human genome. An inconspicuous subunit of its Cas machinery, Cas11, is encoded by a hidden ORF embedded in the cas operon. In human cells, Cas11 is the key enabler for compact CRISPR-Cas3 gene editors.

Identification of genomic enhancers through spatial ...

Single-cell technologies allow measuring chromatin accessibility and gene expression in each cell, but jointly utilizing both layers to map bona fide gene regulatory networks and enhancers remains challenging. Here, we generate …

(PDF) Goodman & Gilman's The Pharmacological Basis of ...

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CRISPR gene editing of major domestication traits ...

Key message Domestication traits particularly fruit size and plant architecture and flowering are critical in transforming a progenitor's wild stature into a super improved plant. The latest advancements in the CRISPR system, as well as its rapid adoption, are speeding up plant breeding. Abstract Solanaceae has a varied range of important crops, with a few model crops, …

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Warzone: 12 Settings That Will Instantly Improve Your ...

Call of Duty: Warzone is a popular shooter, and there are so many settings that players can use to customize their game experience. Things such as sensitivity and tooltips may seem basic to a lot of players, however many other …

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Swap the invul fields for resist specific ones to increase tank. EHP listed below is based on an omni tank with maxed skills. With the Antimatter charges you still get a 54km optimal with 30km falloff. [Rokh, PVE] 8x 425mm Railgun II (Antimatter Charge L) 2x Adaptive Invulnerability Field II. X-Large Shield Booster II.

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1. So last time i ran a L4 sec mission i died horribly, I was under prepared and got one shot right at the start of the mission in a drake.. Yes a drake. Now i have a Machariel and feeling like taking a crack at it again. But i have sunk about 1.4bill into the ship and fit …

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Improved gRNA secondary structures allow editing of …

The first step in CRISPR-Cas9-mediated genome editing is the cleavage of target DNA sequences that are complementary to so-called spacer sequences in CRISPR guide RNAs (gRNAs). However, some DNA ...

Spatial-CUT&Tag: Spatially resolved chromatin …

Chromatin state determines genome function and is regulated in a cell-type-specific manner (1, 2).Despite recent breakthroughs in single-cell sequencing (3–5) that have enabled the profiling of the epigenome in single cells (6–11), it remains challenging to integrate the spatial information of individual cells in the tissue of origin.Here, we report spatial-CUT&Tag for …

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SCI(2019-2020)-MedSci

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Raw Deal Online v.1.0. Raw Deal Online is an client for playing Raw Deal online. It is based off the CCG program Apprentice, but specifically for Raw Deal players. It is usable in Linux, Mac, and Windows, and features support for a Backlash deck, as …

CRISPR Guide - Addgene

Engineered CRISPR systems contain two components: a guide RNA (gRNA or sgRNA) and a CRISPR-associated endonuclease (Cas protein). The gRNA is a short synthetic RNA composed of a scaffold sequence necessary for Cas …

Parallel functional testing identifies enhancers active in ...

Enhancers are cis-regulatory elements that play critical regulatory roles in modulating developmental transcription programs and driving cell-type-specific and context-dependent gene expression in the brain.The development of massively parallel reporter assays (MPRAs) has enabled high-throughput functional screening of candidate DNA sequences for enhancer activity.

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JCI - Welcome

In this issue of the JCI, Tsai et al. present a comprehensive genetic analysis of multiple tumors with acquired sotorasib resistance obtained through an autopsy of a patient with KRAS G12C–mutant NSCLC. This analysis of pre- and posttreatment tumors uncovered cancer cell–intrinsic and –extrinsic features of resistance, including ...

Functional roles of antisense enhancer RNA for promoting ...

Functional roles of antisense enhancer RNA for promoting prostate cancer progression. Chun-Wu Pan 1 *, Simeng Wen 2*, Lei Chen 1, Yulei Wei 3, Yuanjie Niu 2, Yu Zhao 4. 1. Department of Urology, Renji Hospital, School of …

Cas11 enables genome engineering in human cells with ...

In search for a previously uncharacterized compact type I CRISPR, we examined the genomes of Neisseria spp. and identified a previously uncharacterized type I-C CRISPR-Cas locus from the N. lactamica strain ATCC 23970. It consists of a CRISPR array and seven annotated cas genes, including the spacer acquisition genes cas1, cas2, and cas4, the …

Genome organization controls transcriptional dynamics ...

Genome organization is emerging as a potentially important facet of gene regulation (1–5).Because transcriptional enhancers often reside far from their target promoters, chromatin folding may guide the timely and specific establishment of regulatory interactions (1, 3, 4, 6–10).Although long-range enhancer-promoter contacts are prevalent, it remains unclear …